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You will get more health items than you'll ever need from world drops alone. It's in your best interest to avoid buying anything at all during your playthrough (outside of Weapons and upgrades of course). Yup, that's exactly as grindy as it sounds. After you complete that action, you will be unable to do anything other than the main story until Part 2 begins. If you want the exact point the transition to Part 2 begins: It is after you pick up the Vapor Moss by the waterwheel.
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Now's a good time to start finishing up any Part 1 side content you want done. When you recieve a letter from the Mansion, you are getting relatively close. There is no warning as to when the transition is coming. If don't want to start a separate save, make sure you complete the associated content before moving on to Part 2. I will mention which achievements and sidequests are only possible to finish in Part 1. One of the Endings does require a fresh save though, so you can finish any Part 1 achievements there if you don't want to delay your playthrough too much. The repeat playthroughs required for the other Endings will all start you off in Part 2, there is no way back to Part 1 outside of starting a completely new save. At some point, several hours in, an event happens that will move you on to the second Part: Some animals and enemies are replaced, some achievements will be made impossible to finish and all unfinished sidequests will be permanently lost (Except the Fisherman's Gambit). Put as simply as possible, the game has two distinct Parts. Starting a spoiler free guide with an important story moment, not a good start is it? But this is a mechanic of the game that has drastic implications on your playthrough.
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